Research Library / Article Summary
Glutamate- and GABA-targeted drugs for Cc-occurring bipolar and alcohol use disorders: a randomized, double-blind, placebo-controlled, crossover study of N-acetylcysteine, gabapentin, and placebo
Plain-English AddictionTube research summary with source link, DOI, key finding, and recovery relevance.
Translational Psychiatry • 03 Jun 2026 • Research
alcoholbrain sciencemental healthtreatment
Research focus
This article may help explain addiction science through research on alcohol, brain science, mental health, treatment. The source abstract begins by describing: “Forty percent of people with bipolar disorder (BD) develop alcohol use disorder (AUD), with co-occurring AUD substantially worsening the course of BD.”
Why this may help: This may help explain why addiction can involve brain, behavior, mental health, craving, relapse, or treatment factors rather than simple willpower alone. It should be read as research information, not personal medical advice.
This article may help explain addiction science through research on alcohol, cannabis, brain science, withdrawal. The source abstract begins by describing: “Alcohol use disorder (AUD) remains a pervasive public health issue with limited effective treatments.”
Key finding: These findings indicate that chronic CBD administration attenuates both behavioral and neurobiological facets of alcohol dependence by modulating neuronal excitability and preventing neurodegeneration, supporting its therapeutic potential for AUD and providing mechanistic insights for future research.
Neuropsychopharmacology • 10 Jul 2025 • Research
alcoholcannabisbrain sciencewithdrawalrelapsegenetics
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This article may help explain addiction science through research on alcohol, brain science, withdrawal, mental health. The source abstract begins by describing: “Binge drinking is a significant problem in adolescent populations, and because of the reciprocal interactions between ethanol (EtOH) consumption and the endocannabinoid (eCB) system, we sought to determine if adolescent EtOH intake altered the localization…”
Key finding: These findings indicate that repeated exposure to EtOH during adolescence leads to long-term deficits in CB1 receptor expression, eCB-eLTD, and reduced recognition memory, but that these functional deficits can be restored by treatments that increase endogenous 2-arachidonoylglycerol.
Neuropsychopharmacology • 30 Sept 2019 • Research
alcoholbrain sciencewithdrawalmental healthtreatmentanimal study
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This article may help explain addiction science through research on alcohol, cannabis, nicotine, dopamine. The source abstract begins by describing: “In this Opinion article, Nutt and colleagues examine the history of and current evidence for the dopamine theory of addiction.”
Key finding: These observations have implications for understanding reward and treatment responses in various addictions.
Nature Reviews Neuroscience • 15 Apr 2015 • Reviews
alcoholcannabisnicotinedopaminebrain sciencetreatment
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This article may help explain addiction science through research on cannabis, brain science, withdrawal, craving. The source abstract begins by describing: “Cannabis withdrawal in cannabis use disorder (CUD) increase the risk of relapse and lacks effective treatments.”
Key finding: Increases in FAAH (%ΔFAAH whole-brain) were significantly associated with longer cannabis abstinence, greater baseline depression severity, and tendency to act without thinking ( p
Neuropsychopharmacology • 09 May 2026 • Research
cannabisbrain sciencewithdrawalcravingrelapsemental health
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This article may help explain addiction science through research on cocaine, brain science, craving, relapse. The source abstract begins by describing: “Cocaine use disorder represents a public health crisis with no FDA-approved medications for its treatment.”
Key finding: These findings suggest that gut bacteria, via their metabolites, are key regulators of drug-seeking behaviors, positioning the microbiome as a potential translational research target.
Neuropsychopharmacology • 02 Aug 2023 • Research
cocainebrain sciencecravingrelapsemental healthtreatment
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