Research Library / Article Summary

Compulsive-Like Responding for Opioid Analgesics in Rats with Extended Access

Plain-English AddictionTube research summary with source link, DOI, key finding, and recovery relevance.

Neuropsychopharmacology • 25 Jul 2014 • Research

opioidtreatmentanimal study

Research focus

This article may help explain addiction science through research on opioid, treatment, animal study. The source abstract begins by describing: “The abuse of prescription opioids that are used for the treatment of chronic pain is a major public health concern, costing ∼$53.4 billion annually in lost wages, health-care costs, and criminal costs.”

Key finding: The use of extended access models of prescription opioid intake will help better understand the biological factors that underlie opioid dependence.

Why this may help: This may help explain why addiction can involve brain, behavior, mental health, craving, relapse, or treatment factors rather than simple willpower alone. It should be read as research information, not personal medical advice.

Article details

Authors: Carrie L Wade, Leandro F Vendruscolo, George F Koob

DOI: 10.1038/npp2014188

Open access: Not marked open access

Open original source article

Related research topics

Opioid Use Disorder Treatment & Recovery Science Cravings & Relapse

Search similar research

Related article summaries

Acetazolamide inhibition of carbonic anhydrase 4 reverses opioid-induced synaptic rearrangements in nucleus accumbens and reduces drug-seeking behavior

This article may help explain addiction science through research on opioid, cocaine, brain science, withdrawal. The source abstract begins by describing: “Persistent vulnerability to drug-seeking is driven by enduring synaptic adaptations, yet current μ-opioid receptor-targeting pharmacotherapies provide limited efficacy against these neuroadaptations.”

Key finding: By targeting a pathway independent of classical opioid receptor signaling, CA4 inhibition represents a mechanistically distinct strategy that may reduce relapse vulnerability in OUD.

Neuropsychopharmacology • 21 Jan 2026 • Research

opioidcocainebrain sciencewithdrawalrelapsetreatment

Read plain-English summary Open source

Model of negative affect induced by withdrawal from acute and chronic morphine administration in male mice

This article may help explain addiction science through research on opioid, brain science, withdrawal, relapse. The source abstract begins by describing: “Opioid use disorder (OUD) is a chronic relapsing disorder that is a major burden for the lives of affected individuals, and society as a whole.”

Key finding: Altogether, these animal models will contribute to study behavioural and neuronal circuitries involved in the several negative affective signs characterizing OUD.

Scientific Reports • 29 Apr 2024 • Research

opioidbrain sciencewithdrawalrelapsemental healthtreatment

Read plain-English summary Open source

Des-acyl ghrelin reduces alcohol intake and alcohol-induced reward in rodents

This article may help explain addiction science through research on opioid, alcohol, dopamine, brain science. The source abstract begins by describing: “The mechanisms contributing to alcohol use disorder (AUD) are complex and the orexigenic peptide ghrelin, which enhances alcohol reward, is implied as a crucial modulator.”

Key finding: Collectively, our data show that DAG attenuates alcohol-related responses in rodents, an effect opposite to that of ghrelin, and contributes towards a deeper insight into behaviors regulated by the ghrelinergic signaling pathway.

Translational Psychiatry • 04 Jul 2024 • Research

opioidalcoholdopaminebrain sciencetreatmentanimal study

Read plain-English summary Open source

Voluntary alcohol intake alters the motivation to seek intravenous oxycodone and neuronal activation during the reinstatement of oxycodone and sucrose seeking

This article may help explain addiction science through research on opioid, alcohol, dopamine, brain science. The source abstract begins by describing: “Opioid-alcohol polysubstance use is prevalent and worsens treatment outcomes.”

Key finding: Thus, alcohol alters the motivation to seek oxycodone in a sex-dependent manner and the neural circuitry engaged by cue-primed reinstatement of sucrose and oxycodone-seeking.

Scientific Reports • 06 Nov 2023 • Research

opioidalcoholdopaminebrain sciencerelapsetreatment

Read plain-English summary Open source

The protective effect of operant social reward on cocaine self-administration, choice, and relapse is dependent on delay and effort for the social reward

This article may help explain addiction science through research on opioid, cocaine, methamphetamine, relapse. The source abstract begins by describing: “Social reinforcement-based treatments are effective for many, but not all, people with addictions to drugs.”

Key finding: This choice procedure can identify mechanisms of individual differences in an animal model of cocaine use and could thereby help screen medications for people who are relatively unresponsive to treatments based on rewarding social interaction.

Neuropsychopharmacology • 16 Aug 2021 • Research

opioidcocainemethamphetaminerelapsegeneticstreatment

Read plain-English summary Open source

Important: These pages summarize research information and source article records. They are not medical advice, diagnosis, emergency support, or a replacement for qualified treatment. If someone is in immediate danger, contact local emergency services.