This article may help explain addiction science through research on alcohol, dopamine, craving, relapse. The source abstract begins by describing: “Preclinical studies support an important role of dopamine D3 receptors (DRD3s) in alcohol use disorder (AUD).”
Key finding: Furthermore, the finding that binding in the SN is associated with alcohol demand warrants further examination.
Neuropsychopharmacology • 04 Aug 2021 • Research
alcoholdopaminecravingrelapsetreatment
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This article may help explain addiction science through research on cannabis, brain science, withdrawal, craving. The source abstract begins by describing: “Cannabis withdrawal in cannabis use disorder (CUD) increase the risk of relapse and lacks effective treatments.”
Key finding: Increases in FAAH (%ΔFAAH whole-brain) were significantly associated with longer cannabis abstinence, greater baseline depression severity, and tendency to act without thinking ( p
Neuropsychopharmacology • 09 May 2026 • Research
cannabisbrain sciencewithdrawalcravingrelapsemental health
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This article may help explain addiction science through research on alcohol, cannabis, brain science, withdrawal. The source abstract begins by describing: “Alcohol use disorder (AUD) remains a pervasive public health issue with limited effective treatments.”
Key finding: These findings indicate that chronic CBD administration attenuates both behavioral and neurobiological facets of alcohol dependence by modulating neuronal excitability and preventing neurodegeneration, supporting its therapeutic potential for AUD and providing mechanistic insights for future research.
Neuropsychopharmacology • 10 Jul 2025 • Research
alcoholcannabisbrain sciencewithdrawalrelapsegenetics
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This article may help explain addiction science through research on opioid, withdrawal, craving, relapse. The source abstract begins by describing: “Existing pharmacological treatment options for opioid use disorder (OUD) face challenges that limit their efficacy.”
Key finding: This review adopts a translational approach to achieve several aims: (1) to outline the fundamental theories of orexin system function and relate orexinergic dysfunction to the disordered motivation and withdrawal states that characterize OUD; (2) to provide an up-to-date evaluation of preclinical and clinical evidence bases supporting the efficacy of orexin receptor antagonism for the treatment of OUD; (3) to discuss key clinical considerations of repurposing DORAs for OUD treatment, including safety and side effects (i.e., respiratory depression, anhedonia, and risk for abuse); and (4) to highlight the ongoing clinical efforts to determine therapeutic efficacy and safety profiles of DORAs for use in OUD populations.
Translational Psychiatry • 24 Oct 2025 • Reviews
opioidwithdrawalcravingrelapsemental healthtreatment
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This article may help explain addiction science through research on cocaine, brain science, craving, relapse. The source abstract begins by describing: “Cocaine use disorder represents a public health crisis with no FDA-approved medications for its treatment.”
Key finding: These findings suggest that gut bacteria, via their metabolites, are key regulators of drug-seeking behaviors, positioning the microbiome as a potential translational research target.
Neuropsychopharmacology • 02 Aug 2023 • Research
cocainebrain sciencecravingrelapsemental healthtreatment
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