Research Library / Article Summary
Accelerated development of cocaine-associated dopamine transients and cocaine use vulnerability following traumatic stress
Plain-English AddictionTube research summary with source link, DOI, key finding, and recovery relevance.
Neuropsychopharmacology • 20 Sept 2019 • Research
cocainedopaminegeneticsmental healthanimal study
Research focus
This article may help explain addiction science through research on cocaine, dopamine, genetics, mental health. The source abstract begins by describing: “Post-traumatic stress disorder and cocaine use disorder are highly co-morbid psychiatric conditions.”
Key finding: Together, our studies demonstrate that susceptibility to traumatic stress is associated with a cocaine use-vulnerable phenotype and suggests that differences in phasic dopamine signaling architecture may contribute to the process by which this vulnerability occurs.
Why this may help: This may help explain why addiction can involve brain, behavior, mental health, craving, relapse, or treatment factors rather than simple willpower alone. It should be read as research information, not personal medical advice.
This article may help explain addiction science through research on opioid, cocaine, methamphetamine, dopamine. The source abstract begins by describing: “Methamphetamine (METH) is a widely abused psychostimulant, whose hyper-rewarding property is believed to underlie its addictive effect, but the molecular mechanism regulating this effect remains unclear.”
Key finding: Our findings demonstrate an important role for NAc novel-m009C in regulating METH reward, reveal a novel molecular regulator of the actions of METH on brain reward circuitries and provide a new strategy for treating METH addiction based on the modulation of small non-coding RNAs.
Molecular Psychiatry • 17 Jun 2022 • Research
opioidcocainemethamphetaminedopaminebrain sciencegenetics
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This article may help explain addiction science through research on cocaine, dopamine, brain science, craving. The source abstract begins by describing: “The authors show that rostral ventral pallidum projections to the ventral tegmental area (VTA) are activated during cue-induced reinstatement of cocaine seeking, and DREADD inhibition of these projections blocks this behavior.”
Key finding: This double dissociation in ventral pallidum subregional roles in drug seeking is likely to be important for understanding the mesocorticolimbic circuits underlying reward seeking and addiction.
Nature Neuroscience • 02 Mar 2014 • Research
cocainedopaminebrain sciencecravingrelapsegenetics
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This article may help explain addiction science through research on cocaine, methamphetamine, dopamine, brain science. The source abstract begins by describing: “Converging evidence indicates that both dopamine and glutamate neurotransmission within the nucleus accumbens (NAc) play a role in psychostimulant self-administration and relapse in rodent models.”
Key finding: These findings indicate that in contrast to the well-recognized mesoaccumbal dopamine system that is critical to psychostimulant reward and relapse, there is a parallel mesoaccumbal glutamatergic system that suppresses reward and psychostimulant-seeking behavior.
Neuropsychopharmacology • 26 Jun 2024 • Research
cocainemethamphetaminedopaminebrain sciencerelapsegenetics
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This article may help explain addiction science through research on opioid, cocaine, dopamine, brain science. The source abstract begins by describing: “Persistent transcriptional events in ventral tegmental area (VTA) and other reward relevant brain regions contribute to enduring behavioral adaptations that characterize substance use disorder.”
Key finding: These findings establish an essential role for H3Q5dop, and its downstream transcriptional consequences, in heroin-induced functional plasticity in VTA.
Neuropsychopharmacology • 29 Jan 2022 • Research
opioidcocainedopaminebrain sciencerelapsegenetics
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This article may help explain addiction science through research on opioid, dopamine, brain science, withdrawal. The source abstract begins by describing: “The anterior cingulate cortex (ACC) is implicated in many pathologies, including depression, anxiety, substance-use disorders, and pain.”
Key finding: This commonality potentially suggests that the ACC is a locus for multiple withdrawal symptoms.
Neuropsychopharmacology • 02 Aug 2021 • Research
opioiddopaminebrain sciencewithdrawalgeneticsmental health
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