Research focus
This article may help explain addiction science through research on treatment, review. The source abstract begins by describing: “Recent data show that B cells and plasma cells located in tumours or in tumour-draining lymph nodes can have important roles in shaping antitumour immune responses.”
Key finding: B cells can have both protumour and antitumour roles, and the authors discuss the potential of targeting these cells for therapy.
Why this may help: This may help explain why addiction can involve brain, behavior, mental health, craving, relapse, or treatment factors rather than simple willpower alone. It should be read as research information, not personal medical advice.
This article may help explain addiction science through research on alcohol, cannabis, nicotine, dopamine. The source abstract begins by describing: “In this Opinion article, Nutt and colleagues examine the history of and current evidence for the dopamine theory of addiction.”
Key finding: These observations have implications for understanding reward and treatment responses in various addictions.
Nature Reviews Neuroscience • 15 Apr 2015 • Reviews
alcoholcannabisnicotinedopaminebrain sciencetreatment
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This article may help explain addiction science through research on opioid, withdrawal, craving, relapse. The source abstract begins by describing: “Existing pharmacological treatment options for opioid use disorder (OUD) face challenges that limit their efficacy.”
Key finding: This review adopts a translational approach to achieve several aims: (1) to outline the fundamental theories of orexin system function and relate orexinergic dysfunction to the disordered motivation and withdrawal states that characterize OUD; (2) to provide an up-to-date evaluation of preclinical and clinical evidence bases supporting the efficacy of orexin receptor antagonism for the treatment of OUD; (3) to discuss key clinical considerations of repurposing DORAs for OUD treatment, including safety and side effects (i.e., respiratory depression, anhedonia, and risk for abuse); and (4) to highlight the ongoing clinical efforts to determine therapeutic efficacy and safety profiles of DORAs for use in OUD populations.
Translational Psychiatry • 24 Oct 2025 • Reviews
opioidwithdrawalcravingrelapsemental healthtreatment
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This article may help explain addiction science through research on opioid, brain science, relapse, treatment. The source abstract begins by describing: “Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that drive adverse emotional states and relapse.”
Key finding: This Primer by Strang, Volkow and colleagues discusses the risk factors of opioid use disorder, together with its epidemiology, mechanisms, diagnosis and treatment.
Nature Reviews Disease Primers • 09 Jan 2020 • Reviews
opioidbrain sciencerelapsetreatmentreview
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This article may help explain addiction science through research on cannabis, brain science, genetics, mental health. The source abstract begins by describing: “There have been dramatic changes worldwide in the attitudes toward and consumption of recreational and medical cannabis.”
Key finding: Here Ferland and Hurd discuss risk factors related to the development of CUD its neurobiological characteristics.
Nature Neuroscience • 06 Apr 2020 • Reviews
cannabisbrain sciencegeneticsmental healthtreatmentreview
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This article may help explain addiction science through research on opioid, genetics, mental health, treatment. The source abstract begins by describing: “Gambling disorder is characterized by a persistent, recurrent pattern of gambling that is associated with substantial distress or impairment.”
Key finding: This Primer describes the epidemiology, neurobiology, diagnosis, screening, prevention and treatment of this behavioural disorder, and discusses the quality of life of individuals affected.
Nature Reviews Disease Primers • 25 Jul 2019 • Reviews
opioidgeneticsmental healthtreatmentreview
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