Research Library / Article Summary
Gambling disorder
Plain-English AddictionTube research summary with source link, DOI, key finding, and recovery relevance.
Nature Reviews Disease Primers • 25 Jul 2019 • Reviews
opioidgeneticsmental healthtreatmentreview
Research focus
This article may help explain addiction science through research on opioid, genetics, mental health, treatment. The source abstract begins by describing: “Gambling disorder is characterized by a persistent, recurrent pattern of gambling that is associated with substantial distress or impairment.”
Key finding: This Primer describes the epidemiology, neurobiology, diagnosis, screening, prevention and treatment of this behavioural disorder, and discusses the quality of life of individuals affected.
Why this may help: This may help explain why addiction can involve brain, behavior, mental health, craving, relapse, or treatment factors rather than simple willpower alone. It should be read as research information, not personal medical advice.
This article may help explain addiction science through research on opioid, withdrawal, craving, relapse. The source abstract begins by describing: “Existing pharmacological treatment options for opioid use disorder (OUD) face challenges that limit their efficacy.”
Key finding: This review adopts a translational approach to achieve several aims: (1) to outline the fundamental theories of orexin system function and relate orexinergic dysfunction to the disordered motivation and withdrawal states that characterize OUD; (2) to provide an up-to-date evaluation of preclinical and clinical evidence bases supporting the efficacy of orexin receptor antagonism for the treatment of OUD; (3) to discuss key clinical considerations of repurposing DORAs for OUD treatment, including safety and side effects (i.e., respiratory depression, anhedonia, and risk for abuse); and (4) to highlight the ongoing clinical efforts to determine therapeutic efficacy and safety profiles of DORAs for use in OUD populations.
Translational Psychiatry • 24 Oct 2025 • Reviews
opioidwithdrawalcravingrelapsemental healthtreatment
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This article may help explain addiction science through research on opioid, alcohol, cannabis, nicotine. The source abstract begins by describing: “Despite the benefits associated with longer buprenorphine treatment duration (i.e., >180 days) (BTD) for opioid use disorder (OUD), retention remains poor.”
Key finding: Longer BTD is associated with diagnoses of psychiatric and somatic conditions in the EHR, as is the genetic score for OUD, loneliness, problematic alcohol use, and externalizing disorders.
Translational Psychiatry • 10 Jan 2024 • Research
opioidalcoholcannabisnicotinegeneticsmental health
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This article may help explain addiction science through research on cannabis, brain science, genetics, mental health. The source abstract begins by describing: “There have been dramatic changes worldwide in the attitudes toward and consumption of recreational and medical cannabis.”
Key finding: Here Ferland and Hurd discuss risk factors related to the development of CUD its neurobiological characteristics.
Nature Neuroscience • 06 Apr 2020 • Reviews
cannabisbrain sciencegeneticsmental healthtreatmentreview
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This article may help explain addiction science through research on opioid, craving, genetics, mental health. The source abstract begins by describing: “Depression and anxiety frequently co-occur with opioid use disorder (OUD) yet are often overlooked in standard OUD treatments.”
Key finding: Due to the preliminary nature of this pilot study, further research with sample sizes permitting greater statistical power is needed to confirm findings and explore long-term effects.
npj Mental Health Research • 30 Sept 2024 • Research
opioidcravinggeneticsmental healthtreatment
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This article may help explain addiction science through research on alcohol, cannabis, brain science, withdrawal. The source abstract begins by describing: “Alcohol use disorder (AUD) remains a pervasive public health issue with limited effective treatments.”
Key finding: These findings indicate that chronic CBD administration attenuates both behavioral and neurobiological facets of alcohol dependence by modulating neuronal excitability and preventing neurodegeneration, supporting its therapeutic potential for AUD and providing mechanistic insights for future research.
Neuropsychopharmacology • 10 Jul 2025 • Research
alcoholcannabisbrain sciencewithdrawalrelapsegenetics
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