This article may help explain addiction science through research on opioid, alcohol, dopamine, brain science. The source abstract begins by describing: “It is well documented that ethanol exposure alters GABA (γ-aminobutyric acid)-releasing synapses, and ethanol addiction is associated with endogenous opioid system.”
Key finding: These neuroadaptations to ethanol might contribute to early stage of addiction.
Neuropsychopharmacology • 14 Apr 2010 • Research
opioidalcoholdopaminebrain sciencegeneticstreatment
Read plain-English summary Open source
This article may help explain addiction science through research on alcohol, cannabis, nicotine, dopamine. The source abstract begins by describing: “In this Opinion article, Nutt and colleagues examine the history of and current evidence for the dopamine theory of addiction.”
Key finding: These observations have implications for understanding reward and treatment responses in various addictions.
Nature Reviews Neuroscience • 15 Apr 2015 • Reviews
alcoholcannabisnicotinedopaminebrain sciencetreatment
Read plain-English summary Open source
This article may help explain addiction science through research on alcohol, cannabis, brain science, withdrawal. The source abstract begins by describing: “Alcohol use disorder (AUD) remains a pervasive public health issue with limited effective treatments.”
Key finding: These findings indicate that chronic CBD administration attenuates both behavioral and neurobiological facets of alcohol dependence by modulating neuronal excitability and preventing neurodegeneration, supporting its therapeutic potential for AUD and providing mechanistic insights for future research.
Neuropsychopharmacology • 10 Jul 2025 • Research
alcoholcannabisbrain sciencewithdrawalrelapsegenetics
Read plain-English summary Open source
This article may help explain addiction science through research on cocaine, dopamine, brain science, relapse. The source abstract begins by describing: “Cocaine addiction is a significant medical and public concern.”
Key finding: These findings demonstrate that the endogenous ghrelin system plays an important role in cocaine-related addictive behaviors and suggest that manipulating and targeting this system may be viable for mitigating cocaine use disorder.
Neuropsychopharmacology • 18 Dec 2021 • Research
cocainedopaminebrain sciencerelapsegeneticstreatment
Read plain-English summary Open source
This article may help explain addiction science through research on opioid, alcohol, dopamine, brain science. The source abstract begins by describing: “The mechanisms contributing to alcohol use disorder (AUD) are complex and the orexigenic peptide ghrelin, which enhances alcohol reward, is implied as a crucial modulator.”
Key finding: Collectively, our data show that DAG attenuates alcohol-related responses in rodents, an effect opposite to that of ghrelin, and contributes towards a deeper insight into behaviors regulated by the ghrelinergic signaling pathway.
Translational Psychiatry • 04 Jul 2024 • Research
opioidalcoholdopaminebrain sciencetreatmentanimal study
Read plain-English summary Open source