Research Library / Article Summary
Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid
Plain-English AddictionTube research summary with source link, DOI, key finding, and recovery relevance.
Nature Neuroscience • 13 Oct 2013 • Research
cannabisdopaminebrain sciencerelapsetreatment
Research focus
This article may help explain addiction science through research on cannabis, dopamine, brain science, relapse. The source abstract begins by describing: “α7-nicotinic acetylcholine receptors (α7nAChRs) modulate the effects of the main psychoactive ingredient of marijuana, Δ9-tetrahydrocannabinol (THC), in the brain.”
Key finding: Modulation of KYNA offers a pharmacological strategy for achieving abstinence from marijuana and preventing relapse.
Why this may help: This may help explain why addiction can involve brain, behavior, mental health, craving, relapse, or treatment factors rather than simple willpower alone. It should be read as research information, not personal medical advice.
This article may help explain addiction science through research on alcohol, cannabis, nicotine, dopamine. The source abstract begins by describing: “In this Opinion article, Nutt and colleagues examine the history of and current evidence for the dopamine theory of addiction.”
Key finding: These observations have implications for understanding reward and treatment responses in various addictions.
Nature Reviews Neuroscience • 15 Apr 2015 • Reviews
alcoholcannabisnicotinedopaminebrain sciencetreatment
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This article may help explain addiction science through research on cannabis, brain science, withdrawal, craving. The source abstract begins by describing: “Cannabis withdrawal in cannabis use disorder (CUD) increase the risk of relapse and lacks effective treatments.”
Key finding: Increases in FAAH (%ΔFAAH whole-brain) were significantly associated with longer cannabis abstinence, greater baseline depression severity, and tendency to act without thinking ( p
Neuropsychopharmacology • 09 May 2026 • Research
cannabisbrain sciencewithdrawalcravingrelapsemental health
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This article may help explain addiction science through research on alcohol, cannabis, brain science, withdrawal. The source abstract begins by describing: “Alcohol use disorder (AUD) remains a pervasive public health issue with limited effective treatments.”
Key finding: These findings indicate that chronic CBD administration attenuates both behavioral and neurobiological facets of alcohol dependence by modulating neuronal excitability and preventing neurodegeneration, supporting its therapeutic potential for AUD and providing mechanistic insights for future research.
Neuropsychopharmacology • 10 Jul 2025 • Research
alcoholcannabisbrain sciencewithdrawalrelapsegenetics
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This article may help explain addiction science through research on opioid, cannabis, dopamine, brain science. The source abstract begins by describing: “Use of one addictive drug typically influences the behavioral response to other drugs, either administered at the same time or a subsequent time point.”
Key finding: Our study adds to the rich literature on the interaction between drugs, including THC and opioids, and provides potential neural substates by which adolescent THC exposure influences responses to morphine later in life.
Neuropsychopharmacology • 10 Dec 2024 • Research
opioidcannabisdopaminebrain sciencerelapsemental health
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This article may help explain addiction science through research on cocaine, dopamine, brain science, relapse. The source abstract begins by describing: “Cocaine addiction is a significant medical and public concern.”
Key finding: These findings demonstrate that the endogenous ghrelin system plays an important role in cocaine-related addictive behaviors and suggest that manipulating and targeting this system may be viable for mitigating cocaine use disorder.
Neuropsychopharmacology • 18 Dec 2021 • Research
cocainedopaminebrain sciencerelapsegeneticstreatment
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