Research Library / Article Summary
Polysubstance use disorders among US adults
Plain-English AddictionTube research summary with source link, DOI, key finding, and recovery relevance.
Molecular Psychiatry • 29 Apr 2026 • Research
opioidalcoholcocainemethamphetaminecannabisnicotine
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This article may help explain addiction science through research on opioid, alcohol, cocaine, methamphetamine. The source abstract begins by describing: “Polysubstance use disorders ( ≥ 2 substance use disorders (SUDs)) are associated with high morbidity and mortality.”
Key finding: The elevated prevalence of polysubstance use disorders associated with early initiation of substance use underscores the critical need for evidence-based strategies to prevent alcohol, cannabis, and nicotine consumption before age 21.
Why this may help: This may help explain why addiction can involve brain, behavior, mental health, craving, relapse, or treatment factors rather than simple willpower alone. It should be read as research information, not personal medical advice.
This article may help explain addiction science through research on opioid, alcohol, cocaine, methamphetamine. The source abstract begins by describing: “Substance use disorders (SUDs) are common and costly conditions that are partially attributable to genetic factors.”
Key finding: Overall, the findings highlight similarities and differences in immunogenetic profiles of SUDs that may influence the prevalence and co-occurrence of problematic SUDs and may contribute to assessment of SUD risk of an individual on the basis of their HLA genetic makeup.
Scientific Reports • 26 May 2023 • Research
opioidalcoholcocainemethamphetaminecannabisbrain science
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This article may help explain addiction science through research on opioid, alcohol, cannabis, nicotine. The source abstract begins by describing: “Despite the benefits associated with longer buprenorphine treatment duration (i.e., >180 days) (BTD) for opioid use disorder (OUD), retention remains poor.”
Key finding: Longer BTD is associated with diagnoses of psychiatric and somatic conditions in the EHR, as is the genetic score for OUD, loneliness, problematic alcohol use, and externalizing disorders.
Translational Psychiatry • 10 Jan 2024 • Research
opioidalcoholcannabisnicotinegeneticsmental health
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This article may help explain addiction science through research on alcohol, cocaine, methamphetamine, nicotine. The source abstract begins by describing: “Anacker AM, Loftis JM, Ryabinin AE (2011).”
Key finding: Article CAS Google Scholar Download references
Neuropsychopharmacology • 02 Dec 2016 • Research
alcoholcocainemethamphetaminenicotinedopaminerelapse
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This article may help explain addiction science through research on opioid, alcohol, cannabis, nicotine. The source abstract begins by describing: “Substance use disorders (SUDs, including alcohol, cannabis, opioids, and tobacco) represent significant public health challenges.”
Key finding: Lastly, using a real-world dataset, we identified seven SUD-shared genes targeting drugs that may be repurposed for treating SUDs, particularly in those suffering from comorbid SUDs.
Molecular Psychiatry • 07 Oct 2025 • Research
opioidalcoholcannabisnicotinebrain sciencegenetics
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This article may help explain addiction science through research on opioid, alcohol, cocaine, cannabis. The source abstract begins by describing: “Mitchell O, Caudy MS.”
Neuropsychopharmacology • 17 Aug 2021 • Reviews
opioidalcoholcocainecannabistreatmentreview
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