Research Library / Article Summary
Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving
Plain-English AddictionTube research summary with source link, DOI, key finding, and recovery relevance.
Neuropsychopharmacology • 19 Sept 2024 • Research
cocainedopaminecravingrelapseanimal study
Research focus
This article may help explain addiction science through research on cocaine, dopamine, craving, relapse. The source abstract begins by describing: “Relapse represents a consistent clinical problem for individuals with substance use disorder.”
Key finding: These results suggest that DA contributes to incubated cocaine seeking but the emergence of this role reflects changes in postsynaptic responsiveness to DA rather than presynaptic alterations.
Why this may help: This may help explain why addiction can involve brain, behavior, mental health, craving, relapse, or treatment factors rather than simple willpower alone. It should be read as research information, not personal medical advice.
This article may help explain addiction science through research on cocaine, dopamine, brain science, craving. The source abstract begins by describing: “The authors show that rostral ventral pallidum projections to the ventral tegmental area (VTA) are activated during cue-induced reinstatement of cocaine seeking, and DREADD inhibition of these projections blocks this behavior.”
Key finding: This double dissociation in ventral pallidum subregional roles in drug seeking is likely to be important for understanding the mesocorticolimbic circuits underlying reward seeking and addiction.
Nature Neuroscience • 02 Mar 2014 • Research
cocainedopaminebrain sciencecravingrelapsegenetics
Read plain-English summary Open source
This article may help explain addiction science through research on cocaine, dopamine, brain science, craving. The source abstract begins by describing: “Cocaine has actions in the peripheral nervous system that reliably precede—and thus predict—its soon-to-follow central rewarding effects.”
Key finding: These findings suggest that the conditioned peripheral effects of cocaine can contribute significantly to cocaine-induced (but not stress-induced) cocaine craving, and also suggest the cocaine cue as an important target for cue-exposure therapies for cocaine addiction.
Neuropsychopharmacology • 27 Mar 2013 • Research
cocainedopaminebrain sciencecravingrelapseanimal study
Read plain-English summary Open source
This article may help explain addiction science through research on opioid, cocaine, brain science, withdrawal. The source abstract begins by describing: “Evidence indicates that the anterior (aIC), but not posterior (pIC), insular cortex promotes cued reinstatement of cocaine seeking after extinction in rats.”
Key finding: Moreover, the incubation of craving results suggest that new contingency learning is necessary to recruit the aIC in cued heroin seeking.
Neuropsychopharmacology • 18 Mar 2024 • Research
opioidcocainebrain sciencewithdrawalcravingrelapse
Read plain-English summary Open source
This article may help explain addiction science through research on cocaine, brain science, craving, relapse. The source abstract begins by describing: “Cocaine use disorder represents a public health crisis with no FDA-approved medications for its treatment.”
Key finding: These findings suggest that gut bacteria, via their metabolites, are key regulators of drug-seeking behaviors, positioning the microbiome as a potential translational research target.
Neuropsychopharmacology • 02 Aug 2023 • Research
cocainebrain sciencecravingrelapsemental healthtreatment
Read plain-English summary Open source
This article may help explain addiction science through research on cocaine, brain science, craving, relapse. The source abstract begins by describing: “One of the greatest challenges in treating addiction is preventing relapse during abstinence.”
Key finding: Such work has the potential to identify new therapeutic targets and to further our understanding of experience-dependent plasticity in the adult brain under normal circumstances and in the context of addiction.
Nature Reviews Neuroscience • 06 May 2016 • Reviews
cocainebrain sciencecravingrelapsereviewanimal study
Read plain-English summary Open source