Research Library / Article Summary
Evaluating a mobile app’s effects on depression and anxiety in medication-treated opioid use disorder
Plain-English AddictionTube research summary with source link, DOI, key finding, and recovery relevance.
npj Mental Health Research • 30 Sept 2024 • Research
opioidcravinggeneticsmental healthtreatment
Research focus
This article may help explain addiction science through research on opioid, craving, genetics, mental health. The source abstract begins by describing: “Depression and anxiety frequently co-occur with opioid use disorder (OUD) yet are often overlooked in standard OUD treatments.”
Key finding: Due to the preliminary nature of this pilot study, further research with sample sizes permitting greater statistical power is needed to confirm findings and explore long-term effects.
Why this may help: This may help explain why addiction can involve brain, behavior, mental health, craving, relapse, or treatment factors rather than simple willpower alone. It should be read as research information, not personal medical advice.
This article may help explain addiction science through research on opioid, withdrawal, craving, relapse. The source abstract begins by describing: “Existing pharmacological treatment options for opioid use disorder (OUD) face challenges that limit their efficacy.”
Key finding: This review adopts a translational approach to achieve several aims: (1) to outline the fundamental theories of orexin system function and relate orexinergic dysfunction to the disordered motivation and withdrawal states that characterize OUD; (2) to provide an up-to-date evaluation of preclinical and clinical evidence bases supporting the efficacy of orexin receptor antagonism for the treatment of OUD; (3) to discuss key clinical considerations of repurposing DORAs for OUD treatment, including safety and side effects (i.e., respiratory depression, anhedonia, and risk for abuse); and (4) to highlight the ongoing clinical efforts to determine therapeutic efficacy and safety profiles of DORAs for use in OUD populations.
Translational Psychiatry • 24 Oct 2025 • Reviews
opioidwithdrawalcravingrelapsemental healthtreatment
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This article may help explain addiction science through research on opioid, alcohol, cannabis, nicotine. The source abstract begins by describing: “Despite the benefits associated with longer buprenorphine treatment duration (i.e., >180 days) (BTD) for opioid use disorder (OUD), retention remains poor.”
Key finding: Longer BTD is associated with diagnoses of psychiatric and somatic conditions in the EHR, as is the genetic score for OUD, loneliness, problematic alcohol use, and externalizing disorders.
Translational Psychiatry • 10 Jan 2024 • Research
opioidalcoholcannabisnicotinegeneticsmental health
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This article may help explain addiction science through research on dopamine, brain science, craving, genetics. The source abstract begins by describing: “Internet gaming disorder (IGD) has been recognized as a serious mental illness and is often accompanied by depression (IGD-D).”
Key finding: These phenomena were supported by the correlation between FC and behavioral as well as biochemical measures, suggesting that MM is a promising therapy for IGD-D.
Translational Psychiatry • 18 Feb 2026 • Research
dopaminebrain sciencecravinggeneticsmental healthtreatment
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This article may help explain addiction science through research on opioid, genetics, mental health, treatment. The source abstract begins by describing: “Gambling disorder is characterized by a persistent, recurrent pattern of gambling that is associated with substantial distress or impairment.”
Key finding: This Primer describes the epidemiology, neurobiology, diagnosis, screening, prevention and treatment of this behavioural disorder, and discusses the quality of life of individuals affected.
Nature Reviews Disease Primers • 25 Jul 2019 • Reviews
opioidgeneticsmental healthtreatmentreview
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This article may help explain addiction science through research on cannabis, brain science, withdrawal, craving. The source abstract begins by describing: “Cannabis withdrawal in cannabis use disorder (CUD) increase the risk of relapse and lacks effective treatments.”
Key finding: Increases in FAAH (%ΔFAAH whole-brain) were significantly associated with longer cannabis abstinence, greater baseline depression severity, and tendency to act without thinking ( p
Neuropsychopharmacology • 09 May 2026 • Research
cannabisbrain sciencewithdrawalcravingrelapsemental health
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