Research Library / Article Summary
Psilocybin reduces heroin seeking behavior and modulates inflammatory gene expression in the nucleus accumbens and prefrontal cortex of male rats
Plain-English AddictionTube research summary with source link, DOI, key finding, and recovery relevance.
Molecular Psychiatry • 21 Oct 2024 • Research
opioidalcoholnicotinebrain sciencecravingrelapsegeneticsanimal study
Research focus
This article may help explain addiction science through research on opioid, alcohol, nicotine, brain science. The source abstract begins by describing: “Preclinical and human studies indicate psilocybin may reduce perseverant maladaptive behaviors, including nicotine and alcohol seeking.”
Key finding: We conclude that psilocybin reduces heroin relapse and highlight IL-17a signaling as a potential downstream pathway of psilocybin that also reduces heroin seeking.
Why this may help: This may help explain why addiction can involve brain, behavior, mental health, craving, relapse, or treatment factors rather than simple willpower alone. It should be read as research information, not personal medical advice.
This article may help explain addiction science through research on opioid, cocaine, brain science, withdrawal. The source abstract begins by describing: “Evidence indicates that the anterior (aIC), but not posterior (pIC), insular cortex promotes cued reinstatement of cocaine seeking after extinction in rats.”
Key finding: Moreover, the incubation of craving results suggest that new contingency learning is necessary to recruit the aIC in cued heroin seeking.
Neuropsychopharmacology • 18 Mar 2024 • Research
opioidcocainebrain sciencewithdrawalcravingrelapse
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This article may help explain addiction science through research on cocaine, dopamine, brain science, craving. The source abstract begins by describing: “The authors show that rostral ventral pallidum projections to the ventral tegmental area (VTA) are activated during cue-induced reinstatement of cocaine seeking, and DREADD inhibition of these projections blocks this behavior.”
Key finding: This double dissociation in ventral pallidum subregional roles in drug seeking is likely to be important for understanding the mesocorticolimbic circuits underlying reward seeking and addiction.
Nature Neuroscience • 02 Mar 2014 • Research
cocainedopaminebrain sciencecravingrelapsegenetics
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This article may help explain addiction science through research on opioid, cocaine, dopamine, brain science. The source abstract begins by describing: “Persistent transcriptional events in ventral tegmental area (VTA) and other reward relevant brain regions contribute to enduring behavioral adaptations that characterize substance use disorder.”
Key finding: These findings establish an essential role for H3Q5dop, and its downstream transcriptional consequences, in heroin-induced functional plasticity in VTA.
Neuropsychopharmacology • 29 Jan 2022 • Research
opioidcocainedopaminebrain sciencerelapsegenetics
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This article may help explain addiction science through research on alcohol, nicotine, brain science, craving. The source abstract begins by describing: “Chronic alcohol use has important effects on the glutamate system.”
Key finding: These findings provide human evidence consistent with a robust preclinical literature supporting mGlu5 receptor drugs as pharmacotherapies for AUD.
Neuropsychopharmacology • 12 Sept 2020 • Research
alcoholnicotinebrain sciencecravingrelapse
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This article may help explain addiction science through research on opioid, alcohol, dopamine, brain science. The source abstract begins by describing: “Opioid-alcohol polysubstance use is prevalent and worsens treatment outcomes.”
Key finding: Thus, alcohol alters the motivation to seek oxycodone in a sex-dependent manner and the neural circuitry engaged by cue-primed reinstatement of sucrose and oxycodone-seeking.
Scientific Reports • 06 Nov 2023 • Research
opioidalcoholdopaminebrain sciencerelapsetreatment
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