Research Library / Article Summary
Longitudinal imaging of metabotropic glutamate 5 receptors during early and extended alcohol abstinence
Plain-English AddictionTube research summary with source link, DOI, key finding, and recovery relevance.
Neuropsychopharmacology • 12 Sept 2020 • Research
alcoholnicotinebrain sciencecravingrelapse
Research focus
This article may help explain addiction science through research on alcohol, nicotine, brain science, craving. The source abstract begins by describing: “Chronic alcohol use has important effects on the glutamate system.”
Key finding: These findings provide human evidence consistent with a robust preclinical literature supporting mGlu5 receptor drugs as pharmacotherapies for AUD.
Why this may help: This may help explain why addiction can involve brain, behavior, mental health, craving, relapse, or treatment factors rather than simple willpower alone. It should be read as research information, not personal medical advice.
This article may help explain addiction science through research on opioid, alcohol, nicotine, brain science. The source abstract begins by describing: “Preclinical and human studies indicate psilocybin may reduce perseverant maladaptive behaviors, including nicotine and alcohol seeking.”
Key finding: We conclude that psilocybin reduces heroin relapse and highlight IL-17a signaling as a potential downstream pathway of psilocybin that also reduces heroin seeking.
Molecular Psychiatry • 21 Oct 2024 • Research
opioidalcoholnicotinebrain sciencecravingrelapse
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This article may help explain addiction science through research on alcohol, brain science, craving, relapse. The source abstract begins by describing: “The Neural Craving Signature (NCS), a machine learning derived neuroimaging biomarker, differentiates individuals with from those without substance use disorders (SUDs), but has not been evaluated for predicting clinical outcomes.”
Key finding: These findings provide initial support for the NCS as a predictor of clinical outcomes in AUD.
Neuropsychopharmacology • 25 Feb 2026 • Research
alcoholbrain sciencecravingrelapse
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This article may help explain addiction science through research on alcohol, cannabis, nicotine, dopamine. The source abstract begins by describing: “In this Opinion article, Nutt and colleagues examine the history of and current evidence for the dopamine theory of addiction.”
Key finding: These observations have implications for understanding reward and treatment responses in various addictions.
Nature Reviews Neuroscience • 15 Apr 2015 • Reviews
alcoholcannabisnicotinedopaminebrain sciencetreatment
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This article may help explain addiction science through research on cannabis, brain science, withdrawal, craving. The source abstract begins by describing: “Cannabis withdrawal in cannabis use disorder (CUD) increase the risk of relapse and lacks effective treatments.”
Key finding: Increases in FAAH (%ΔFAAH whole-brain) were significantly associated with longer cannabis abstinence, greater baseline depression severity, and tendency to act without thinking ( p
Neuropsychopharmacology • 09 May 2026 • Research
cannabisbrain sciencewithdrawalcravingrelapsemental health
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This article may help explain addiction science through research on alcohol, cannabis, brain science, withdrawal. The source abstract begins by describing: “Alcohol use disorder (AUD) remains a pervasive public health issue with limited effective treatments.”
Key finding: These findings indicate that chronic CBD administration attenuates both behavioral and neurobiological facets of alcohol dependence by modulating neuronal excitability and preventing neurodegeneration, supporting its therapeutic potential for AUD and providing mechanistic insights for future research.
Neuropsychopharmacology • 10 Jul 2025 • Research
alcoholcannabisbrain sciencewithdrawalrelapsegenetics
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